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Editorial
. 2010 Nov;128(11):1483-5.
doi: 10.1001/archophthalmol.2010.245.

Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle

Krzysztof Palczewski
Editorial

Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle

Krzysztof Palczewski. Arch Ophthalmol. 2010 Nov.
No abstract available

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Figures

Figure
Figure
Treatment of Briard Rpe65−/−-mutant dogs with the synthetic cis-retinoids. A, View of a treated Briard Rpe65−/−-mutant dog. B, Chemistry of vision: phototransduction and the retinoid (visual) cycle (reviewed in von Lintig et al). Mutations in Rpe65 are associated with Leber congenital amaurosis because they are required for 11-cis-retinal production. 9-cis-Retinoids can be used to overcome this blockage and regenerate functional visual pigments, called isorhodopsin, in rods that have characteristics similar to rhodopsin. The depicted protein structures are of rhodopsin (left) and Rpe65 (right).
See this image and copyright information in PMC

Comment on

References

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