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Case Reports
. 2010 Aug 27;4(2):298-303.
doi: 10.1159/000314821.

Extrapulmonary Small Cell Carcinoma of the Stomach: A Lethal Entity

Duane Moise  1 , Jaspreet Singh, Keith Dahl, Sadat Rashid, Apsara Prasad, Ghulam Siddiqui, Krishnaiyer Subramani, Paul Mustacchia, Kaleem Rizvon
Affiliations
Case Reports

Extrapulmonary Small Cell Carcinoma of the Stomach: A Lethal Entity

Duane Moise et al. Case Rep Gastroenterol. .

Abstract

Extrapulmonary small cell carcinoma of the stomach is a rare and aggressive malignancy with a poor prognosis that was first described in 1976 by Matsusaka et al. In 1989 it was recognized by the World Health Organization as an independent entity affecting the stomach. Pure and composite are the two types of gastric small cell carcinoma reported in the literature. We report a case of a 68-year-old African American male with metastatic pure-type extrapulmonary small cell cancer of the stomach. The primary lesion measured approximately 7 cm in diameter on endoscopy. The diagnosis was made on the basis of characteristic histological features of small, round, oval lymphocyte-like cells with hyperchromatic nuclei, and scant cytoplasm consistent with small cell carcinoma. Gastric small cell carcinoma is typically diagnosed at an advanced stage as demonstrated in our case. We conducted a literature review discussing the two types of extrapulmonary small cell carcinoma of the stomach and their prevalence.

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Figures

Fig. 1
Fig. 1
Moderate ascites, heterogenous thickening surrounding the gastric fundus, omental caking, nodular shrunken liver consistent with cirrhosis.
Fig. 2
Fig. 2
Endoscopic retroflexed view of the fundal mass.
Fig. 3
Fig. 3
Small, round lymphocyte-like cells with hyperchromatic nuclei, scant cytoplasm and frequent mitosis on light microscopy.
See this image and copyright information in PMC

References

    1. Cioppa T, Marrelli D, Neri A, Caruso S, Pedrazzani C, Malagnino V, Pinto E, Roviello F. A case of small-cell gastric carcinoma with an adenocarcinoma component and hepatic metastasis: treatment with systemic and intra-hepatic chemotherapy. Eur J Cancer Care. 2007;16:453–457. - PubMed
    1. Namikawa T, Kobayashi M, Okabayashi T, Ozaki S, Nakamura S, Yamashita K, Ueta H, Miyazaki J, Tamura S, Ohtsuki Y, Araki K. Primary gastric small cell carcinoma: report of a case and review of the literature. Med Mol Morphol. 2005;38:256–261. - PubMed
    1. Hussein AM, Otrakji CL, Hussein BT. Small cell carcinoma of the stomach: case report and review of the literature. Dig Dis Sci. 1990;35:513–518. - PubMed
    1. Kim JH, Lee SH, Paek J, Kim HY, Lee SI, Nam WM, Park JO, Kim K, Jung CW, Im YH, Kang WK, Lee MH, Park K. Extrapulmonary small-cell carcinoma: a single-institution experience. Jpn J Clin Oncol. 2004;34:250–254. - PubMed
    1. Brenner B, Tang LH, Klimstra DS, Kelsen DP. Small cell carcinoma of the gastrointestinal tract: a review. J Clin Oncol. 2004;22:2730–2739. - PubMed

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