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Review
. 2010;13(6):669-84.

Pictet-Spengler reactions for the synthesis of pharmaceutically relevant heterocycles

Affiliations
  • PMID: 21061230
Review

Pictet-Spengler reactions for the synthesis of pharmaceutically relevant heterocycles

Karolina Pulka. Curr Opin Drug Discov Devel. 2010.

Abstract

The synthesis of biologically active heterocyclic scaffolds is one of the significant challenges of modern synthetic chemistry. The Pictet-Spengler (PS) reaction, known for approximately a century, remains a particularly popular cyclization method. This review describes recent applications of the PS reaction in the total synthesis of alkaloids and biologically active analogs of tetrahydroisoquinoline and tetrahydro-β-carboline. The utility of PS cyclization in the synthesis of a range of heterocyclic scaffolds is also described.

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