Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Feb;87(4):1591-5.
doi: 10.1073/pnas.87.4.1591.

Transforming growth factor beta decreases the immunogenicity of rat islet xenografts (rat to mouse) and prevents rejection in association with treatment of the recipient with a monoclonal antibody to interferon gamma

J C Carel  1 , R D Schreiber, L Falqui, P E Lacy
Affiliations

Transforming growth factor beta decreases the immunogenicity of rat islet xenografts (rat to mouse) and prevents rejection in association with treatment of the recipient with a monoclonal antibody to interferon gamma

J C Carel et al. Proc Natl Acad Sci U S A. 1990 Feb.

Abstract

Culture of rat islets of Langerhans for 1 week at 37 degrees C with recombinant transforming growth factor beta prolonged the survival of islet xenografts transplanted into diabetic mouse recipients. Treatment of diabetic recipients with a neutralizing monoclonal antibody to murine interferon gamma did not affect the survival of islet xenografts cultured 7 days in control medium. However, treatment of donor islets with transforming growth factor beta in combination with treatment of diabetic recipients with interferon gamma antibody produced a 75% survival of the islet xenografts at 100 days. Fifty percent of the recipients who had accepted their graft for more than 100 days were immune unresponsive to a transplant of freshly isolated islets from the same donor strain.

PubMed Disclaimer

References

    1. Science. 1988 Oct 7;242(4875):97-9 - PubMed
    1. Nature. 1988 Jul 21;334(6179):260-2 - PubMed
    1. Transplantation. 1989 May;47(5):761-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4282-6 - PubMed
    1. Diabetes. 1967 Jan;16(1):35-9 - PubMed

Publication types

MeSH terms

Substances