Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010;15(1):13-25.
doi: 10.3727/105221610x12819686555051.

Emerging roles for XBP1, a sUPeR transcription factor

Yin He  1 , Shengyi Sun, Haibo Sha, Ziying Liu, Liu Yang, Zhen Xue, Hui Chen, Ling Qi
Affiliations
Free PMC article
Review

Emerging roles for XBP1, a sUPeR transcription factor

Yin He et al. Gene Expr. 2010.
Free PMC article

Abstract

X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of homeostasis in the endoplasmic reticulum (ER) and activation of the unfolded protein response (UPR). XBP1, first identified as a key regulator of major histocompatibility complex (MHC) class II gene expression in B cells, represents the most conserved signaling component of UPR and is critical for cell fate determination in response to ER stress. Here we review recent advances in our understanding of this multifaceted transcription factor in health and diseases.

PubMed Disclaimer

References

    1. Trends Genet. 2006 Dec;22(12):645-8 - PubMed
    1. Nucleic Acids Res. 1996 May 15;24(10):1855-64 - PubMed
    1. Nature. 1996 Feb 29;379(6568):821-3 - PubMed
    1. Nature. 2010 Feb 25;463(7284):1092-5 - PubMed
    1. Nature. 2008 Aug 21;454(7207):961-7 - PubMed

Publication types

Substances