β-lactam antibiotics in continuous infusion in critically ill patients

Comment

Axel Jeurissen et al. Crit Care. 2010.

. 2010;14(5):446; author reply 446.

doi: 10.1186/cc9288. Epub 2010 Oct 26.

No abstract available

Comment on

Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock.
Taccone FS, Laterre PF, Dugernier T, Spapen H, Delattre I, Wittebole X, De Backer D, Layeux B, Wallemacq P, Vincent JL, Jacobs F. Taccone FS, et al. Crit Care. 2010;14(4):R126. doi: 10.1186/cc9091. Epub 2010 Jul 1. Crit Care. 2010. PMID: 20594297 Free PMC article.

1. Taccone FS, Laterre PF, Dugernier T, Spapen H, Delattre I, Witebolle X, De Backer D, Layeux B, Wallemacq P, Vincent JL, Jacobs F. Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock. Crit Care. 2010;14:R126. doi: 10.1186/cc9091. - DOI - PMC - PubMed
1. Vincent JL, Rello J, Marshal J, Eliezer S, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K. for the EPIC II Group of Investigators. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009;302:2323–2329. doi: 10.1001/jama.2009.1754. - DOI - PubMed
1. Belgian Isepamycin Multicentre Group. Comparative in vitro activity of isepamycin and other antibiotics against gram-negative bacilli from intensive care units (ICU) in Belgium. Acta Clin Belg. 2001;56:307–315. - PubMed
1. Roberts JA, Lipman J, Blot S, Rello J. Better outcomes through continuous infusion of time-dependent antibiotics to critically ill patients? Curr Opin Crit Care. 2008;14:390–396. doi: 10.1097/MCC.0b013e3283021b3a. - DOI - PubMed
1. Page MG, Heim J. Prospects for the next anti-Pseudomonas drug. Curr Opin Pharmacol. 2009;9:558–565. doi: 10.1016/j.coph.2009.08.006. - DOI - PubMed