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. 2011 Jan;39(Database issue):D913-9.
doi: 10.1093/nar/gkq1128. Epub 2010 Nov 9.

Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

Faviel F Gonzalez-Galarza  1 , Stephen Christmas, Derek Middleton, Andrew R Jones
Affiliations

Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations

Faviel F Gonzalez-Galarza et al. Nucleic Acids Res. 2011 Jan.

Abstract

The allele frequency net database (http://www.allelefrequencies.net) is an online repository that contains information on the frequencies of immune genes and their corresponding alleles in different populations. The extensive variability observed in genes and alleles related to the immune system response and its significance in transplantation, disease association studies and diversity in populations led to the development of this electronic resource. At present, the system contains data from 1133 populations in 608,813 individuals on the frequency of genes from different polymorphic regions such as human leukocyte antigens, killer-cell immunoglobulin-like receptors, major histocompatibility complex Class I chain-related genes and a number of cytokine gene polymorphisms. The project was designed to create a central source for the storage of frequency data and provide individuals with a set of bioinformatics tools to analyze the occurrence of these variants in worldwide populations. The resource has been used in a wide variety of contexts, including clinical applications (histocompatibility, immunology, epidemiology and pharmacogenetics) and population genetics. Demographic information, frequency data and searching tools can be freely accessed through the website.

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Figures

Figure 1.
Figure 1.
Screen shot of the HLA AFS. The figure shows an example of a search of the HLA-A*02:01 allele sorted by highest to lowest frequencies. Other data provided includes a link to the IMGT/HLA database for sequence information of the allele, link to frequency distribution maps, haplotype association of the allele and additional notes. The information provided can be printed to include all records.
Figure 2.
Figure 2.
Screen shot of the KIR genotype frequency search. The figure displays a view of the first 10 genotypes found in three populations (China Eastern Mainland Han, Ghana and Iran) sorted by the number of individuals on which the genotype has been reported in worldwide populations.
See this image and copyright information in PMC

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