Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jan 4;104(1):33-6.
doi: 10.1038/sj.bjc.6605983. Epub 2010 Nov 9.

Rab25 as a tumour suppressor in colon carcinogenesis

J R Goldenring  1 , K T Nam
Affiliations
Review

Rab25 as a tumour suppressor in colon carcinogenesis

J R Goldenring et al. Br J Cancer. .

Abstract

Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpression is associated with ovarian cancer aggressive behaviour, Rab25 expression is decreased in human colon cancers independent of stage. Recent studies of mouse models of intestinal and colonic neoplasia have demonstrated that Rab25 deficiency markedly promotes the development of neoplasia. Some of these effects appear related to alterations in β1-integrin trafficking to the cell surface. These findings all suggest that Rab25 is a tumour suppressor for colonic neoplasia.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A scheme for regulation of transformation and cell polarity by Rab25. The figure shows the possible interactions of vesicle recycling through recycling endosomes (RE) of either signalling receptors (on the left) or polarity-related proteins (on the right). Loss of Rab25 in colon cells could lead to either direct dysregulation of these pathways or imbalances in parallel trafficking pathways regulated by Rab11a or by alteration of influences on downstream shared effectors such as Rab11-FIP1C (also known as RCP). Effects of Rab25 on transcription remain unknown, although there is no evidence that Rab25 ever enters the nucleus.
See this image and copyright information in PMC

References

    1. Balzac F, Avolio M, Degani S, Kaverina I, Torti M, Silengo L, Small JV, Retta SF (2005) E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J Cell Sci 118(Part 20): 4765–4783 - PubMed
    1. Casanova JE, Wang X, Kumar R, Bhartur SG, Navarre J, Woodrum JE, Altschuler Y, Ray GS, Goldenring JR (1999) Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell 10(1): 47–61 - PMC - PubMed
    1. Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC (2007) Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13(4): 496–510 - PubMed
    1. Chen HC, Chu RY, Hsu PN, Hsu PI, Lu JY, Lai KH, Tseng HH, Chou NH, Huang MS, Tseng CJ, Hsiao M (2003) Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas. Cancer Lett 201(1): 97–106 - PubMed
    1. Cheng JM, Ding M, Aribi A, Shah P, Rao K (2006) Loss of RAB25 expression in breast cancer. Int J Cancer 118(12): 2957–2964 - PubMed

Publication types

LinkOut - more resources