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. 1990 Jan;43(1):8-18.
doi: 10.7164/antibiotics.43.8.

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

K Sugawara  1 , M Hatori, Y Nishiyama, K Tomita, H Kamei, M Konishi, T Oki
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Free article

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

K Sugawara et al. J Antibiot (Tokyo). 1990 Jan.
Free article

Abstract

Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L- serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.

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