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. 2010 Nov 10:8:115.
doi: 10.1186/1479-5876-8-115.

High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study

Michele Guida  1 , Antonio Cramarossa, Ettore Fistola, Mariangela Porcelli, Giuseppe Giudice, Katia Lubello, Giuseppe Colucci
Affiliations

High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study

Michele Guida et al. J Transl Med. .
No abstract available

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Figures

Figure 1
Figure 1
Complete response in patient with mediastinal lymphopaty and bowel metastases treated in Cohort A (schedule d1,8-28).
Figure 2
Figure 2
Dramatic partial response in patient with liver, lymph nodes and subcutaneous metastases treated in Cohort B (schedule d1-21).
Figure 3
Figure 3
Pathological features of a subcutaneous lesion biopsied after 3 cycles of therapy showing a diffuse regression of the neoplastic cells with abundant melanocitic pigment.
Figure 4
Figure 4
Immunohistochemistry staining showed a strong positivity of the neoplastic component for S100 protein, HMB 45 and MART 1. Moreover, an impressive lymphocytic (CD3+, CD4+, CD8+) and macrophage cells (CD68+) infiltration was present.
See this image and copyright information in PMC

References

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