Proposed revision to the radiation dosimetry of 82Rb

Abstract

Three models for the biodistribution and dosimetry of 82Rb-chloride were reviewed and a proposal is made for the best dosimetry for this agent to be adopted. Data from three proposed biokinetic models for 82Rb-chloride were used to calculate dose estimates for the compound, and the results were compared. The blood content-based model was found to produce dose estimates that were considered to be overly conservative, and a blood flow-based model, which showed good agreement with available measured data, was considered to be more reasonable. A new set of dose estimates for 82Rb-chloride, based on the blood flow-based kinetic model are suggested for general use.