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. 2010 Dec 6;6(23):2678-82.
doi: 10.1002/smll.201001447.

Gd-labeled microparticles in MRI: in vivo imaging of microparticles after intraperitoneal injection

Jeremy L Steinbacher  1 , Sherrill A Lathrop, Kai Cheng, Jedd M Hillegass, Kelly J Butnor, Risto A Kauppinen, Brooke T Mossman, Christopher C Landry
Affiliations

Gd-labeled microparticles in MRI: in vivo imaging of microparticles after intraperitoneal injection

Jeremy L Steinbacher et al. Small. .
No abstract available

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Figures

Figure 1
Figure 1
(a) Illustration of the modified microparticles, (b) SEM image of Gd-loaded microparticles, and (c) N2 physisorption isotherms and BET surface areas at subsequent stages of the synthesis.
Figure 2
Figure 2
Magnetic resonance images of one Wistar rat injected IP with Gd-loaded microparticles, focusing on the lower abdominal cavity. Enhanced contrast in the bladder at early time points is indicated by the arrows, showing that a fraction of the microparticles were excreted in the urine.
Figure 3
Figure 3
Sagittal MR image of a C57BL/6 mouse injected IP with APMS-DTPA/Gd-TEG. The particles appear as a bowl-shaped region of contrast in the bladder, and the ureter is also visible (white arrow). Because the animal was lying on its back, these images suggest that the particles were settling under the influence of gravity.
Figure 4
Figure 4
SEM and EDS analyses (probe target highlighted in circles) of rat urine excreted at 2 hr, showing Gd-loaded APMS microparticles.
See this image and copyright information in PMC

References

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