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. 2010 Dec 15;20(24):7205-11.
doi: 10.1016/j.bmcl.2010.10.116. Epub 2010 Oct 27.

Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents

Koneni V Sashidhara  1 , Abdhesh Kumar, Manoj Kumar, Jayanta Sarkar, Sudhir Sinha
Affiliations

Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents

Koneni V Sashidhara et al. Bioorg Med Chem Lett. .

Abstract

A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 and 26) showed IC(50) range from 3.59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM.

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