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. 2011 Jan;39(Database issue):D1171-6.
doi: 10.1093/nar/gkq998. Epub 2010 Nov 11.

The IMGT/HLA database

James Robinson  1 , Kavita Mistry, Hamish McWilliam, Rodrigo Lopez, Peter Parham, Steven G E Marsh
Affiliations

The IMGT/HLA database

James Robinson et al. Nucleic Acids Res. 2011 Jan.

Abstract

It is 12 years since the IMGT/HLA database was first released, providing the HLA community with a searchable repository of highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and are highly polymorphic. The naming of these HLA genes and alleles and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics Institute, we are able to provide public access to this data through the web site http://www.ebi.ac.uk/imgt/hla/. Regular updates to the web site ensure that new and confirmatory sequences are dispersed to the HLA community, and the wider research and clinical communities.

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Figures

Figure 1.
Figure 1.
World map showing the source and volume of IMGT/HLA submissions by country.
Figure 2.
Figure 2.
Graph of the number of submissions to the IMGT/HLA database by year. The recent surge in the number of submissions received by the database is clearly shown. The values listed for 2010 are up to the end of September 2010, and do not represent a full year.
Figure 3.
Figure 3.
Heat maps of the polymorphic amino acid positions in HLA-B. The two sets of maps show the increase in the number of polymorphic positions identified between the first release of the database in 1998 (A) and the latest release in 2010 (B). The x-axis is the amino acid position and the y-axis the number of different amino acids seen at that position.
See this image and copyright information in PMC

References

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