Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jan 19;46(1):R1-9.
doi: 10.1677/JME-10-0122. Print 2011 Feb.

Selective estrogen receptor modulators as brain therapeutic agents

María Angeles Arevalo  1 , María Santos-Galindo, Natalia Lagunas, Iñigo Azcoitia, Luis M Garcia-Segura
Affiliations
Free article
Review

Selective estrogen receptor modulators as brain therapeutic agents

María Angeles Arevalo et al. J Mol Endocrinol. .
Free article

Abstract

Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.

PubMed Disclaimer

Publication types

MeSH terms