Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2011 Jan;20(1):23-32.
doi: 10.1158/1055-9965.EPI-10-0698. Epub 2010 Nov 11.

Validation of genome-wide prostate cancer associations in men of African descent

Bao-Li Chang  1 , Elaine Spangler, Stephen Gallagher, Christopher A Haiman, Brian Henderson, William Isaacs, Marnita L Benford, LaCreis R Kidd, Kathleen Cooney, Sara Strom, Sue Ann Ingles, Mariana C Stern, Roman Corral, Amit D Joshi, Jianfeng Xu, Veda N Giri, Benjamin Rybicki, Christine Neslund-Dudas, Adam S Kibel, Ian M Thompson, Robin J Leach, Elaine A Ostrander, Janet L Stanford, John Witte, Graham Casey, Rosalind Eeles, Ann W Hsing, Stephen Chanock, Jennifer J Hu, Esther M John, Jong Park, Klara Stefflova, Charnita Zeigler-Johnson, Timothy R Rebbeck
Affiliations
Multicenter Study

Validation of genome-wide prostate cancer associations in men of African descent

Bao-Li Chang et al. Cancer Epidemiol Biomarkers Prev. 2011 Jan.

Abstract

Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent.

Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci.

Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2.

Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.

Impact: The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Results of Prostate Cancer Associations at 8q24 in ADM. P-values for association by genomic location.
See this image and copyright information in PMC

References

    1. Gudmundsson J, Sulem P, Rafnar T, et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet. 2008;40:281–3. - PMC - PubMed
    1. Eeles RA, Kote-Jarai Z, Giles GG, et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet. 2008;40:316–21. - PubMed
    1. Thomas G, Jacobs KB, Yeager M, et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008;40:310–5. - PubMed
    1. Duggan D, Zheng SL, Knowlton M, et al. Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP. J Natl Cancer Inst. 2007;99:1836–44. - PubMed
    1. Lou H, Yeager M, Li H, et al. Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proc Natl Acad Sci U S A. 2009;106:7933–8. - PMC - PubMed

Publication types