Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Oct;5(10):1539-51.
doi: 10.2217/fmb.10.116.

The Streptococcus pyogenes proteome: maps, virulence factors and vaccine candidates

Alexander V Dmitriev  1 , Michael S Chaussee
Affiliations
Review

The Streptococcus pyogenes proteome: maps, virulence factors and vaccine candidates

Alexander V Dmitriev et al. Future Microbiol. 2010 Oct.

Abstract

Streptococcus pyogenes is an important cause of human morbidity and mortality worldwide. A wealth of genomic information related to this pathogen has facilitated exploration of the proteome, particularly in response to environmental conditions thought to mimic various aspects of pathogenesis. Proteomic approaches are also used to identify immunoreactive proteins for vaccine development and to identify proteins that may induce autoimmunity. These studies have revealed new mechanisms involved in regulating the S. pyogenes proteome, which has opened up new avenues in the study of S. pyogenes pathogenesis. This article describes the methods used, and progress being made towards characterizing the S. pyogenes proteome, including studies seeking to identify potential vaccine candidates.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Predicted 2-DE map of the Streptococcus pyogenes SF370 proteome
The mass and pI of the 1697 predicted open reading frames in strain SF370 were determined using ExPASy [101].
Figure 2
Figure 2. Comparison of protein abundance between the wild-type and rgg mutant strains in postexponential and exponential phases of growth, respectively
The amount of each protein spot identified in the wild-type strain during the postexponential growth was compared to the matched spot in an rgg mutant strain during the exponential phase of growth (r = 0.9).
See this image and copyright information in PMC

References

Bibliography

    1. Neuner JM, Hamel MB, Phillips RS, Bona K, Aronson MD. Diagnosis and management of adults with pharyngitis A cost–effectiveness analysis. Ann Intern Med. 2003;139(2):113–122. - PubMed
    1. Cunningham MW. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev. 2000;13(3):470–511. - PMC - PubMed
    1. Shulman ST. Pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS): update. Curr Opin Pediatr. 2009;21(1):127–130. - PubMed
    1. Pavone P, Parano E, Rizzo R, Trifiletti RR. Autoimmune neuropsychiatric disorders associated with streptococcal infection: Sydenham chorea, pandas, and pandas variants. J Child Neurol. 2006;21(9):727–736. - PubMed
    1. Reichert TA, Simonsen L, Sharma A, Pardo SA, Fedson DS, Miller MA. Influenza and the winter increase in mortality in the united states, 1959–1999. Am J Epidemiol. 2004;160:492–502. - PubMed

Website

    1. ExPASy. http://us.expasy.org.

Publication types

MeSH terms