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. 2010 Oct;8(7):498-503.
doi: 10.2174/157016210793499187.

Analysis of HIV tropism in Ugandan infants

Jessica D Church  1 , Wei Huang, Anthony Mwatha, Philippa Musoke, J Brooks Jackson, Danstan Bagenda, Saad B Omer, Deborah Donnell, Clemensia Nakabiito, Chineta Eure, Laura A Guay, Allan Taylor, Paul M Bakaki, Flavia Matovu, Michelle McConnell, Mary Glenn Fowler, Susan H Eshleman
Affiliations

Analysis of HIV tropism in Ugandan infants

Jessica D Church et al. Curr HIV Res. 2010 Oct.

Abstract

HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).

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Conflict of interest statement

CONFLICT OF INTEREST

Wei Huang is anemployee of Monogram Biosciences. Susan Eshleman is a member of the Clinical Advisory Board of Monogram Biosciences.

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