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. 1990 Mar 15;344(6263):219-23.
doi: 10.1038/344219a0.

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

G Reuter  1 , M Giarre, J Farah, J Gausz, A Spierer, P Spierer
Affiliations

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein

G Reuter et al. Nature. .

Abstract

Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.

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