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. 2012 Feb;33(2):425.e1-2.
doi: 10.1016/j.neurobiolaging.2010.10.002. Epub 2010 Nov 12.

Analysis of optineurin in frontotemporal lobar degeneration

Sara Rollinson  1 , Janis Bennion, Greg Toulson, Nicola Halliwell, Suzanne Usher, Julie Snowden, Anna Richardson, David Neary, David Mann, Stuart M Pickering-Brown
Affiliations

Analysis of optineurin in frontotemporal lobar degeneration

Sara Rollinson et al. Neurobiol Aging. 2012 Feb.

Abstract

Frontotemporal lobar degeneration (FTLD) can occur jointly with amyotrophic lateral sclerosis (ALS), and these 2 conditions share a genetic risk factor on chromosome 9. It has been reported that mutations in optineurin (OPTN) can cause ALS. Therefore, we sequenced OPTN in 371 FTLD cases but no mutations were detected, suggesting changes in OPTN do not cause FTLD.

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