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Comparative Study
. 1990 Feb 25;18(4):1037-43.
doi: 10.1093/nar/18.4.1037.

Identification of a second inducible DNA-protein interaction in the kappa immunoglobulin enhancer

K Nelms  1 , R Hromas, B Van Ness
Affiliations
Free PMC article
Comparative Study

Identification of a second inducible DNA-protein interaction in the kappa immunoglobulin enhancer

K Nelms et al. Nucleic Acids Res. .
Free PMC article

Abstract

Control of kappa immunoglobulin light-chain gene expression requires the interaction of tissue specific and developmentally regulated DNA-binding proteins with the kappa gene enhancer. Deletion of enhancer sequences upstream from the NF-kB binding site has been shown to impair enhancer function, implying additional proteins may interact with these sequences. In surveying this region for sites of protein binding, a novel DNA-protein interaction, designated kBF-A, was detected. The binding activity of this factor appears to be specific to activated pre-B cells and correlates with high level induction of kappa transcription in these cells.

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References

    1. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1482-6 - PubMed
    1. Nature. 1988 May 5;333(6168):40-5 - PubMed
    1. Nucleic Acids Res. 1988 Jun 10;16(11):4967-88 - PubMed
    1. Science. 1988 Oct 28;242(4878):540-6 - PubMed
    1. Mol Cell Biol. 1988 Nov;8(11):4972-80 - PubMed

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