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Case Reports
. 2012 Jan;30(1):252.e5-9.
doi: 10.1016/j.ajem.2010.09.039. Epub 2010 Nov 13.

Ciprofloxacin-induced torsade de pointes

Morhaf Ibrahim  1 , Bassam Omar
Affiliations
Case Reports

Ciprofloxacin-induced torsade de pointes

Morhaf Ibrahim et al. Am J Emerg Med. 2012 Jan.

Abstract

A 65-year-old man with recently diagnosed urinary tract infection treated with ciprofloxacin (Cipro) presented to our institution with recurrent seizure-like activity. His rhythm revealed torsade de pointes, which required defibrillation. Subsequent electrocardiogram revealed severely prolonged QT interval, which near-completely resolved 7 days later off Cipro. This case highlights a rare but potentially fatal side effect of quinolone antibiotics, especially in combination with other QT-prolonging medications. Review of the literature with regard to prevalence, mechanism, and assessment and treatment of this potentially fatal incidence is provided.

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