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Review
. 2010:2010:517493.
doi: 10.1155/2010/517493. Epub 2010 Nov 4.

Dendritic cell-based immunotherapy for prostate cancer

Hanka Jähnisch  1 , Susanne Füssel, Andrea Kiessling, Rebekka Wehner, Stefan Zastrow, Michael Bachmann, Ernst Peter Rieber, Manfred P Wirth, Marc Schmitz
Affiliations
Review

Dendritic cell-based immunotherapy for prostate cancer

Hanka Jähnisch et al. Clin Dev Immunol. 2010.

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells (APCs), which display an extraordinary capacity to induce, sustain, and regulate T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Thus, clinical trials enrolling prostate cancer patients were conducted, which were based on the administration of DCs loaded with tumor-associated antigens. These clinical trials revealed that DC-based immunotherapeutic strategies represent safe and feasible concepts for the induction of immunological and clinical responses in prostate cancer patients. In this context, the administration of the vaccine sipuleucel-T consisting of autologous peripheral blood mononuclear cells including APCs, which were pre-exposed in vitro to the fusion protein PA2024, resulted in a prolonged overall survival among patients with metastatic castration-resistant prostate cancer. In April 2010, sipuleucel-T was approved by the United States Food and Drug Administration for prostate cancer therapy.

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Figures

Figure 1
Figure 1
DC-based immunotherapeutic strategies for prostate cancer. DCs display a unique capacity to induce and maintain T-cell responses and emerged as promising candidates for vaccination strategies in prostate cancer therapy. Thus, DCs are loaded with PCa-associated antigen-derived peptides, protein, or RNA. Due to their high surface expression of HLA-peptide-complexes and costimulatory molecules, DCs efficiently activate and expand CD8+ CTLs and CD4+ T cells. CD8+ CTLs possess a profound capability to recognize and destroy tumor cells. CD4+ T cells enhance the capacity of DCs to induce CTLs by the interaction between CD40 on DCs and CD40 ligand on activated CD4+ T cells. In addition, they provide help for the maintenance and expansion of CTLs by secreting cytokines and are able to eradicate tumor cells directly. CTLs: cytotoxic T cells; DCs: dendritic cells; HLA: human leukocyte antigen; IL: interleukin; IFN: interferon; TCR: T cell receptor; TU: tumor cells.
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References

    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer Journal for Clinicians. 2009;59(4):225–249. - PubMed
    1. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Annals of Oncology. 2007;18(3):581–592. - PubMed
    1. Heidenreich A, Aus G, Bolla M, et al. EAU guidelines on prostate cancer. European Urology. 2008;53(1):68–80. - PubMed
    1. Damber J-E, Aus G. Prostate cancer. The Lancet. 2008;371(9625):1710–1721. - PubMed
    1. Roehl KA, Han M, Ramos CG, Antenor JAV, Catalona WJ. Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. The Journal of Urology. 2004;172(3):910–914. - PubMed

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