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. 2011 Sep;33(3):409-19.
doi: 10.1007/s11357-010-9192-2. Epub 2010 Nov 13.

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

Davide Seripa  1 , Giulia Paroni, Maria G Matera, Carolina Gravina, Carlo Scarcelli, Michele Corritore, Luigi P D'Ambrosio, Maria Urbano, Grazia D'Onofrio, Massimiliano Copetti, Patrick G Kehoe, Francesco Panza, Alberto Pilotto
Affiliations

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

Davide Seripa et al. Age (Dordr). 2011 Sep.

Abstract

The association between angiotensin-converting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.

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