Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;55(2):925-8.
doi: 10.1128/AAC.00949-10. Epub 2010 Nov 15.

Human tissue distribution of voriconazole

Stefan Weiler  1 , David Fiegl, Róisín MacFarland, Eva Stienecke, Rosa Bellmann-Weiler, Stefan Dunzendorfer, Michael Joannidis, Romuald Bellmann
Affiliations

Human tissue distribution of voriconazole

Stefan Weiler et al. Antimicrob Agents Chemother. 2011 Feb.

Abstract

Voriconazole concentrations were determined in autopsy samples of eight patients who had been treated for a median of 7 days (interquartile range [IQR], 5 days). Voriconazole penetrates well into various tissues, with median levels of 6.26 μg/g ((interquartile range [IQR], 7.87 μg/g) in the lung, 3.41 μg/g (IQR, 16.72 μg/g) in the brain, 6.89 μg/g (IQR, 24.16 μg/g) in the liver, 6.47 μg/g (IQR, 6.19 μg/g) in the kidneys, 5.60 μg/g (IQR, 11.49 μg/g) in the spleen, and 7.55 μg/g (IQR, 16.91 μg/g) in the myocardium.

PubMed Disclaimer

References

    1. Ballesta, S., I. Garcia, E. J. Perea, and A. Pascual. 2005. Uptake and intracellular activity of voriconazole in human polymorphonuclear leucocytes. J. Antimicrob. Chemother. 55:785-787. - PubMed
    1. Burhenne, J., W. E. Haefeli, M. Hess, and A. Scope. 2008. Pharmacokinetics, tissue concentrations, and safety of the antifungal agent voriconazole in chickens. J. Avian Med. Surg. 22:199-207. - PubMed
    1. Capitano, B., et al. 2006. Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen. Antimicrob. Agents Chemother. 50:1878-1880. - PMC - PubMed
    1. Colitz, C. M., et al. 2007. Pharmacokinetics of voriconazole following intravenous and oral administration and body fluid concentrations of voriconazole following repeated oral administration in horses. Am. J. Vet. Res. 68:1115-1121. - PubMed
    1. Crandon, J. L., et al. 2009. Bronchopulmonary disposition of intravenous voriconazole and anidulafungin given in combination to healthy adults. Antimicrob. Agents Chemother. 53:5102-5107. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources