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. 2011 Jan;55(1):414-6.
doi: 10.1128/AAC.00991-10. Epub 2010 Nov 15.

Cold shock induces qnrA expression in Shewanella algae

Hong Bin Kim  1 , Chi Hye Park, Mariah Gavin, George A Jacoby, David C Hooper
Affiliations

Cold shock induces qnrA expression in Shewanella algae

Hong Bin Kim et al. Antimicrob Agents Chemother. 2011 Jan.

Abstract

Plasmid-carried quinolone resistance genes, like qnrA, are widespread in Enterobacteriaceae. To gain insight into its little-understood native functions, we studied the effect of environmental conditions on chromosomal qnrA expression in Shewanella algae. Among conditions of DNA damage, oxidative and osmotic stress, starvation, heat, and cold, only cold shock increased gene expression, as measured by quantitative reverse transcription-PCR (qRT-PCR). Induction was graded and occurred during growth arrest, suggesting that qnrA may contribute to the adaptation of Shewanella to low temperatures.

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References

    1. Brune, M., R. Schumann, and F. Wittinghofer. 1985. Cloning and sequencing of the adenylate kinase gene (adk) of Escherichia coli. Nucleic Acids Res. 13:7139-7151. - PMC - PubMed
    1. Cattoir, V., L. Poirel, D. Mazel, C. J. Soussy, and P. Nordmann. 2007. Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants. Antimicrob. Agents Chemother. 51:2650-2651. - PMC - PubMed
    1. Ding, Y., Y. Onodera, J. C. Lee, and D. C. Hooper. 2008. NorB, an efflux pump in Staphylococcus aureus MW2, contributes to bacterial fitness in abscesses. J. Bacteriol. 190:7123-7129. - PMC - PubMed
    1. Erill, I., M. Escribano, S. Campoy, and J. Barbé. 2003. In silico analysis reveals substantial variability in the gene contents of the gamma proteobacterial LexA-regulon. Bioinformatics 19:2225-2236. - PubMed
    1. Gao, H., Y. Wang, X. Liu, T. Yan, L. Wu, E. Alm, A. Arkin, D. K. Thompson, and J. Zhou. 2004. Global transcriptome analysis of the heat shock response of Shewanella oneidensis. J. Bacteriol. 186:7796-7803. - PMC - PubMed

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