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. 2010 Nov 15;21(22):3793-4.
doi: 10.1091/mbc.E10-08-0726.

Change, change, change: heeding the call

Francis S Collins  1
Affiliations

Change, change, change: heeding the call

Francis S Collins. Mol Biol Cell. .
No abstract available

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Figures

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Francis S. Collins
Figure 1.
Figure 1.
Left, dramatic nuclear blebbing of fibroblasts from a patient with Hutchinson-Gilford progeria syndrome (HGPS). Right, nuclear blebbing of HGPS fibroblasts corrected by treatment with a farnesyl transferase inhibitor. Credit: Brian Capell, nHGRI.
See this image and copyright information in PMC

References

    1. Capell B. C., Erdos M. R., Madigan J. P., Fiordalisi J. J., Varga R., Conneely K. N., Gordon L. B., Der C. J., Cox A. D., Collins F. S. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA. 2005;102:12879–12884. - PMC - PubMed
    1. Collins F. S. Research agenda: opportunities for research and NIH. Science. 2010;327:36–37. - PubMed
    1. Eriksson M., et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 2003;423:293–298. - PMC - PubMed
    1. Goldman R. D., et al. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA. 2004;101:8963–8968. - PMC - PubMed
    1. Kieran M. W., Gordon L., Kleinman M. New approaches to progeria. Pediatrics. 2007;120:834–841. - PubMed

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