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Comment
. 2010 Nov 15;191(4):699-700.
doi: 10.1083/jcb.201010082.

Platelet precursors display bipolar behavior

Hansjörg Schwertz  1 , Andrew S Weyrich
Affiliations
Comment

Platelet precursors display bipolar behavior

Hansjörg Schwertz et al. J Cell Biol. .

Abstract

In this issue, Thon et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201006102) demonstrate that newly released platelets exhibit bipolar behavior, shifting back and forth between round cells and multibodied proplatelets (Thon et al., 2010). The authors define this intermediate as a preplatelet and, in doing so, shed new insight into the terminal steps of platelet maturation.

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Figures

Figure 1.
Figure 1.
Platelet precursors display bipolar behavior. In this issue, Thon et al. (2010) demonstrate that platelet precursors shift back and forth between two morphological poles, one that is discoid and the other that has barbell-like features (i.e., proplatelets). The authors name the discoid precursor a preplatelet. Both preplatelets and proplatelets contribute to the mature platelet pool.
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