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. 2010 Dec;6(12):857-9.
doi: 10.1038/nchembio.488.

Grand challenge commentary: Informative diagnostics for personalized medicine

Affiliations

Grand challenge commentary: Informative diagnostics for personalized medicine

Ryan C Bailey. Nat Chem Biol. 2010 Dec.

Abstract

Some of the most celebrated triumphs of chemical biology are molecularly targeted therapeutics to combat human disease. However, a grand challenge looms as informative diagnostic strategies must be developed to realize the full impact of these promising pharmaceutical agents.

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Figures

Figure 1
Figure 1
Beyond drug discovery and target validation, there are numerous opportunities for chemical biologists to accelerate the realization of personalized medicine.

References

    1. Consortium IHGS. Initial sequencing and analysis of the human genome. Nature. 2001;409:860–921. - PubMed
    1. Venter JC, et al. The sequence of the human genome. Science. 2001;291:1304–1351. - PubMed
    1. Druker BJ, et al. Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia. N Engl J Med. 2001;344:1031–1037. - PubMed
    1. Lynch TL, et al. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib. N Engl J Med. 2004;350:2129–2139. - PubMed
    1. Paez JG, et al. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy. Science. 2004;304:1497–1500. - PubMed