Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec;6(12):861-3.
doi: 10.1038/nchembio.479.

Grand challenge commentary: Accessing new chemical space for 'undruggable' targets

Sivaraman Dandapani  1 , Lisa A Marcaurelle
Affiliations

Grand challenge commentary: Accessing new chemical space for 'undruggable' targets

Sivaraman Dandapani et al. Nat Chem Biol. 2010 Dec.

Abstract

The synthesis and biological annotation of small molecules from underexplored chemical space will play a central role in the development of drugs for challenging targets currently being identified in frontier areas of biological research such as human genetics.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18787-92 - PubMed
    1. J Med Chem. 2009 Nov 12;52(21):6752-6 - PubMed
    1. Nat Chem Biol. 2005 Jul;1(2):74-84 - PubMed
    1. Curr Opin Chem Biol. 2010 Jun;14(3):362-70 - PubMed
    1. Science. 2010 Sep 3;329(5996):1175-80 - PubMed

Substances

LinkOut - more resources