Grand challenge commentary: The chemistry of a dynamic genome
- PMID: 21079591
- DOI: 10.1038/nchembio.471
Grand challenge commentary: The chemistry of a dynamic genome
Abstract
In the postsequencing era, chemical biology is uniquely situated to investigate genomic DNA alterations arising through epigenetic modifications, genetic rearrangements or active mutation. These transformations significantly expand nature's diversity and may profoundly alter our view of DNA's coding potential.
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