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Review
. 2010 Dec;8(12):857-66.
doi: 10.1038/nrmicro2457.

RNAs: regulators of bacterial virulence

Jonas Gripenland  1 , Sakura Netterling, Edmund Loh, Teresa Tiensuu, Alejandro Toledo-Arana, Jörgen Johansson
Affiliations
Review

RNAs: regulators of bacterial virulence

Jonas Gripenland et al. Nat Rev Microbiol. 2010 Dec.

Abstract

RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria.

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References

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