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Review
. 2010 Dec;8(12 Suppl):S7-16.
doi: 10.1038/nrmicro2460.

Dengue: a continuing global threat

Maria G Guzman  1 , Scott B Halstead, Harvey Artsob, Philippe Buchy, Jeremy Farrar, Duane J Gubler, Elizabeth Hunsperger, Axel Kroeger, Harold S Margolis, Eric Martínez, Michael B Nathan, Jose Luis Pelegrino, Cameron Simmons, Sutee Yoksan, Rosanna W Peeling
Affiliations
Review

Dengue: a continuing global threat

Maria G Guzman et al. Nat Rev Microbiol. 2010 Dec.

Abstract

Dengue fever and dengue haemorrhagic fever are important arthropod-borne viral diseases. Each year, there are ∼50 million dengue infections and ∼500,000 individuals are hospitalized with dengue haemorrhagic fever, mainly in Southeast Asia, the Pacific and the Americas. Illness is produced by any of the four dengue virus serotypes. A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated. Antiviral drugs and vaccines that are currently under development could also make an important contribution to dengue control in the future.

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Figures

Figure 1
Figure 1. Countries and areas at risk of dengue transmission, 2007
Data from WHO.
Figure 2
Figure 2. The dengue virus genome
The single open reading frame encodes three structural proteins (the capsid (C), membrane (M) and envelope (E) glycoproteins) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and N55).
Figure 3
Figure 3. The change in distribution of dengue serotypes
The figure shows the distribution in 1970 (a) and 2004 (b). Reproduced with permission from REF. 141.
Figure 4
Figure 4. Dengue virus, antigen and antibody responses used in diagnosis
Ig, immunoglobulin; NS, non-structural.
See this image and copyright information in PMC

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