Large placebo-controlled RCT in myocardial infarction survivors finds that daily folic acid and vitamin B12 have no effect on risk of major vascular event

Affiliations

Comment

Alessandro Pezzini. Evid Based Med. 2011 Feb.

. 2011 Feb;16(1):12-3.

doi: 10.1136/ebm1131. Epub 2010 Nov 16.

¹ Dipartimento di Scienze Mediche e Chirurgiche, Clinica Neurologica, Università degli Studi di Brescia, Brescia, Italia. ale_pezzini@hotmail.com

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Comment on

Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group; Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, Parish S, Sleight P, Peto R, Collins R. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, et al. JAMA. 2010 Jun 23;303(24):2486-94. doi: 10.1001/jama.2010.840. JAMA. 2010. PMID: 20571015 Clinical Trial.