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. 2010 Nov 16;15(11):8251-9.
doi: 10.3390/molecules15118251.

Pancreatic lipase inhibition by C-glycosidic flavones Isolated from Eremochloa ophiuroides

Eun Mi Lee  1 , Seung Sik Lee, Byung Yeoup Chung, Jae-Young Cho, In Chul Lee, So Ra Ahn, Soo Jeung Jang, Tae Hoon Kim
Affiliations

Pancreatic lipase inhibition by C-glycosidic flavones Isolated from Eremochloa ophiuroides

Eun Mi Lee et al. Molecules. .

Abstract

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-ß-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC₅₀ values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.

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Figures

Figure 1
Figure 1
Structures of compounds 1–9 isolated from E. ophiuroides.
Figure 2
Figure 2
Selected HMBC and NOESY correlations of compound 1.
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