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. 2010 Nov 16;15(11):8366-76.
doi: 10.3390/molecules15118366.

Median lethal dose, antimalarial activity, phytochemical screening and radical scavenging of methanolic Languas galanga rhizome extract

Abdulelah H Al-Adhroey  1 , Zurainee M Nor, Hesham M Al-Mekhlafi, Rohela Mahmud
Affiliations

Median lethal dose, antimalarial activity, phytochemical screening and radical scavenging of methanolic Languas galanga rhizome extract

Abdulelah H Al-Adhroey et al. Molecules. .

Abstract

The methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes. The antimalarial activities during early and established infections, as well as the prophylactic activity were evaluated. Phytochemical screening and radical scavenging activity of the extract were also investigated to elucidate the possible mechanism of the antimalarial properties. The acute oral toxicity (LD₅₀) of Languas galanga extract in mice was established to be 4.998 mg/kg. The extract of Languas galanga rhizomes demonstrated significant antiplasmodial activity in all the three models of the antimalarial evaluations. Phytochemical screening revealed the presence of some vital antiplasmodial constituents such as terpenoids and flavonoids. The extract also exhibited a moderate capacity to scavenge the free radicals. The rhizome extract of Languas galanga thus possesses antimalarial activity, which explains the rational usage of this plant in traditional Malaysian medicine.

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Figures

Figure 1
Figure 1
DPPH radical scavenging activities of the methanolic extract of Languas galanga rhizomes, ascorbic acid and gallic acid at different concentrations of µg/mL. Absorbance values represent means of triplicates of different concentrations analyzed.
See this image and copyright information in PMC

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