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. 2010 Dec 28;4(12):7467-74.
doi: 10.1021/nn102644u. Epub 2010 Nov 17.

A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment

Ya-Ling Chiu  1 , Show-An Chen, Jean-Hong Chen, Ko-Jie Chen, Hsin-Lung Chen, Hsing-Wen Sung
Affiliations

A dual-emission Förster resonance energy transfer nanoprobe for sensing/imaging pH changes in the biological environment

Ya-Ling Chiu et al. ACS Nano. .

Abstract

A dual-emission nanoprobe that can sense changes in the environmental pH is designed based on the concept of pH-responsive Förster resonance energy transfer induced by the conformational transition of an associating polyelectrolyte, N-palmitoyl chitosan, bearing a donor (Cy3) or an acceptor (Cy5) moiety. We demonstrate that the developed pH-responsive nanoprobe can be used to ratiometrically image and thus discriminate the pH changes in the biological environment at different length scales.

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