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Review
. 2010 Nov;5(6):947-59.
doi: 10.2217/rme.10.79.

Myc transcription factors: key regulators behind establishment and maintenance of pluripotency

Keriayn Smith  1 , Stephen Dalton
Affiliations
Review

Myc transcription factors: key regulators behind establishment and maintenance of pluripotency

Keriayn Smith et al. Regen Med. 2010 Nov.

Abstract

The interplay between transcription factors, epigenetic modifiers, chromatin remodelers and miRNAs form the foundation of a complex regulatory network required for establishment and maintenance of the pluripotent state. Recent work indicates that Myc transcription factors are essential elements of this regulatory system. However, despite numerous studies, aspects of how Myc controls self-renewal and pluripotency remain obscure. This article reviews evidence supporting the placement of Myc as a central regulator of the pluripotent state and discusses possible mechanisms of action.

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Figures

Figure 1
Figure 1. Roles for Myc in maintaining PSCs
Myc regulates establishment and maintenance of pluripotency using diverse mechanisms.
Figure 2
Figure 2. Myc participates in many aspects of the multistep process to reprogram somatic cells to the pluripotent state
See this image and copyright information in PMC

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