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Review
. 2010;30(5):463-87.
doi: 10.1615/critrevimmunol.v30.i5.50.

Inflammasomes and their activation

Sonal Khare  1 , Nancy Luc, Andrea Dorfleutner, Christian Stehlik
Affiliations
Review

Inflammasomes and their activation

Sonal Khare et al. Crit Rev Immunol. 2010.

Abstract

The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition receptors that activate inflammasomes in macrophages. Inflammasomes are protein platforms essential for the activation of inflammatory caspases and subsequent maturation of their pro-inflammatory cytokine substrates and induction of pyroptosis. This paper summarizes recent developments regarding the function of Nod-like receptors in immunity and disease.

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Figures

FIGURE 1
FIGURE 1
Domain structure of NLR and adaptor proteins involved in inflammasome activation. Proteins were analyzed using the simple modular architecture research tool (SMART) (http://smart.embl.de/), and conserved domains are indicated.
FIGURE 2
FIGURE 2
Composition and activators of known inflammasomes. Known and putative inflammasomes are shown. Inflammatory diseases caused by mutations or polymorphisms of inflammasome proteins are indicated by an asterisk. A question mark indicates that the inflammasome agonist or precise inflammasome composition is not known.
See this image and copyright information in PMC

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