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. 2010 Nov 17:8:142.
doi: 10.1186/1477-7827-8-142.

Metabolic abnormalities in adolescents with polycystic ovary syndrome in south China

Jia Huang  1 , Renmin Ni, Xiaoli Chen, Lili Huang, Yaqin Mo, Dongzi Yang
Affiliations

Metabolic abnormalities in adolescents with polycystic ovary syndrome in south China

Jia Huang et al. Reprod Biol Endocrinol. .

Abstract

Background: Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential risk factors contributed to these health risks.

Methods: Anthropometric measurements and biochemical parameters were evaluated in 128 adolescents with PCOS and their age- and BMI-matched controls.

Results: The prevalence of pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome in adolescents with PCOS was 11.7%, 46.9%, 29.7%, 22.7% and 4.7%, respectively. 16.3%, 74.4%, 67.4%, 39.5% and 14% of the PCOS subjects with BMI > 85th had pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome, whereas 9.4%, 32.9%, 10.6%, 14.1% and 0% of the PCOS subjects with BMI < 85th had such disturbances.

Conclusions: Adolescents with PCOS in South China had more metabolic abnormalities than their age- and BMI-matched non-PCOS counterparts. Obesity could worsen insulin resistance, hyperinsulinemia and metabolic syndrome in PCOS adolescents.

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Figures

Figure 1
Figure 1
Odds ratio for four clinical disorders in BMI ≥85th versus BMI < 85th groups of adolescents with PCOS. PCOS was defined by Rotterdam criteria.
See this image and copyright information in PMC

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