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Review
. 2011 May;11(5):593-6.
doi: 10.1016/j.intimp.2010.11.005. Epub 2010 Nov 24.

3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance

Fang Zhou  1 , Guang-Xian Zhang, Abdolmohamad Rostami
Affiliations
Review

3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance

Fang Zhou et al. Int Immunopharmacol. 2011 May.

Abstract

3G11 is a sialylated carbohydrate epitope of the disialoganglioside molecule expressed on mouse CD4(+) T cells. Recent research showed that 3G11 expression is related to the modulation of T cell function, i.e., 3G11(-) T cells exhibit anergic/Treg characteristics and efficiently inhibit autoimmunity in the central nervous system. The relationship between 3G11 expression and immune tolerance is summarized in this literature review.

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Conflict of interest statement

The authors have no financial conflict of interest.

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