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Review
. 2011 May;11(5):593-6.
doi: 10.1016/j.intimp.2010.11.005. Epub 2010 Nov 24.

3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance

Fang Zhou  1 , Guang-Xian Zhang, Abdolmohamad Rostami
Affiliations
Review

3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance

Fang Zhou et al. Int Immunopharmacol. 2011 May.

Abstract

3G11 is a sialylated carbohydrate epitope of the disialoganglioside molecule expressed on mouse CD4(+) T cells. Recent research showed that 3G11 expression is related to the modulation of T cell function, i.e., 3G11(-) T cells exhibit anergic/Treg characteristics and efficiently inhibit autoimmunity in the central nervous system. The relationship between 3G11 expression and immune tolerance is summarized in this literature review.

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Conflict of interest statement

The authors have no financial conflict of interest.

References

    1. Rudick RA, Polman CH. Current approaches to the identification and management of breakthrough disease in patients with multiple sclerosis. Lancet Neurol. 2009;8:545–559. - PubMed
    1. Imitola J, Chitnis T, Khoury SJ. Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Ther. 2005;106:163–177. - PubMed
    1. Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX. Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain. 2007;130:490–501. - PubMed
    1. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421:744–748. - PubMed
    1. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 2005;201:233–240. - PMC - PubMed

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