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Comment
. 2010 Nov 30;107(48):20597-8.
doi: 10.1073/pnas.1015420107. Epub 2010 Nov 17.

How T cells take developmental decisions by using the aryl hydrocarbon receptor to sense the environment

Thomas Korn  1
Affiliations
Comment

How T cells take developmental decisions by using the aryl hydrocarbon receptor to sense the environment

Thomas Korn. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Although Th1 (TH1) and Th2 (TH2) cells fail to up-regulate AHR, this ligand-driven transcription factor is expressed in Th17 (TH17) cells, Foxp3+ Tregs, and Tr-1 cells. Ligation of AHR with particular ligands, such as TCDD, 6-formylindolo-(3,2-b)-carbazole (FICZ), ITE, or endogenous ligands, likely promotes and stabilizes the transcriptional program of the AHR-expressing T-cell subsets (in the text and refs. 2, 3, 13, 14). It is interesting to hypothesize (and with the available tools, it can now be tested) whether AHR ligation might also convert precommitted precursors of one T-cell lineage into another T-cell subset, and thus exhibit truly immunomodulatory properties. TC, T cell.
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References

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