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Comment

. 2010 Nov 30;107(48):20599-600.

doi: 10.1073/pnas.1015563107. Epub 2010 Nov 17.

Are oncogenes sufficient to cause human cancer?

Scott E Woodman¹, Gordon B Mills

Affiliations

PMID: 21084639
PMCID: PMC2996413
DOI: 10.1073/pnas.1015563107

Comment

Are oncogenes sufficient to cause human cancer?

Scott E Woodman et al. Proc Natl Acad Sci U S A. 2010.

. 2010 Nov 30;107(48):20599-600.

doi: 10.1073/pnas.1015563107. Epub 2010 Nov 17.

Authors

Scott E Woodman¹, Gordon B Mills

Affiliation

¹ Melanoma Medical Oncology, Systems Biology, Kleberg Center for Molecular Markers, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 21084639
PMCID: PMC2996413
DOI: 10.1073/pnas.1015563107

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Comment on

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors.
Hafner C, Toll A, Fernández-Casado A, Earl J, Marqués M, Acquadro F, Méndez-Pertuz M, Urioste M, Malats N, Burns JE, Knowles MA, Cigudosa JC, Hartmann A, Vogt T, Landthaler M, Pujol RM, Real FX. Hafner C, et al. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20780-5. doi: 10.1073/pnas.1008365107. Epub 2010 Nov 15. Proc Natl Acad Sci U S A. 2010. PMID: 21078999 Free PMC article.

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References

1. Hafner C, et al. Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci USA. 2010;107:20780–20785. - PMC - PubMed
1. Blomberg M, Jeppesen EM, Skovby F, Benfeldt E. FGFR3 mutations and the skin: Report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature. Dermatology. 2010;220:297–305. - PubMed
1. Otto W, et al. No mutations of FGFR3 in normal urothelium in the vicinity of urothelial carcinoma of the bladder harbouring activating FGFR3 mutations in patients with bladder cancer. Int J Cancer. 2009;125:2205–2208. - PubMed
1. Hernández S, et al. FGFR3 mutations in prostate cancer: Association with low-grade tumors. Mod Pathol. 2009;22:848–856. - PubMed
1. Negrini S, Gorgoulis VG, Halazonetis TD. Genomic instability—an evolving hallmark of cancer. Nat Rev Mol Cell Biol. 2010;11:220–228. - PubMed

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