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. 2010 Dec;37(12):1241-8.
doi: 10.1007/s10295-010-0849-8. Epub 2010 Nov 18.

Do we need new antibiotics? The search for new targets and new compounds

Jaroslav Spížek  1 , Jitka Novotná, Tomáš Rezanka, Arnold L Demain
Affiliations

Do we need new antibiotics? The search for new targets and new compounds

Jaroslav Spížek et al. J Ind Microbiol Biotechnol. 2010 Dec.

Abstract

Resistance to antibiotics and other antimicrobial compounds continues to increase. There are several possibilities for protection against pathogenic microorganisms, for instance, preparation of new vaccines against resistant bacterial strains, use of specific bacteriophages, and searching for new antibiotics. The antibiotic search includes: (1) looking for new antibiotics from nontraditional or less traditional sources, (2) sequencing microbial genomes with the aim of finding genes specifying biosynthesis of antibiotics, (3) analyzing DNA from the environment (metagenomics), (4) re-examining forgotten natural compounds and products of their transformations, and (5) investigating new antibiotic targets in pathogenic bacteria.

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References

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