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Meta-Analysis
. 2010 Nov 21;16(43):5510-7.
doi: 10.3748/wjg.v16.i43.5510.

Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis

Jia-Li Liu  1 , Yuan Liang, Zhen-Ning Wang, Xin Zhou, Li-Li Xing
Affiliations
Meta-Analysis

Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis

Jia-Li Liu et al. World J Gastroenterol. .

Abstract

Aim: To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis.

Methods: Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE, EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR) with 95% confidence interval (CI) was calculated.

Results: Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C, -1195A, -1290G, *2430T alleles and *429TT genotype revealed increased risk for GC (OR = 1.71, 95% CI: 1.01-2.90, P = 0.05; OR = 1.58, 95% CI: 1.05-2.38, P = 0.03; OR = 1.55, 95% CI: 1.01-2.39, P = 0.05; OR = 2.62, 95% CI: 1.20-5.73, P = 0.02 and OR = 0.74, 95% CI: 0.59-0.95, P = 0.02, respectively).

Conclusion: The -765C, -1195A, -1290G, *2430T alleles and *429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC.

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Figures

Figure 1
Figure 1
Flow chart showing study selection procedure. COX: Cyclooxygenases.
Figure 2
Figure 2
Meta-analysis of the association between cyclooxygenases-2 polymorphisms and susceptibility to gastric cancer.
Figure 3
Figure 3
Subgroup analysis of -765G>C polymorphism by ethnicity.
Figure 4
Figure 4
Sensitivity analysis of -765G>C polymorphism.
Figure 5
Figure 5
Funnel plots to explore publication bias.
See this image and copyright information in PMC

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