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. 2011 Feb;32(2):403-7.
doi: 10.3174/ajnr.A2289. Epub 2010 Nov 18.

Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy

N Sudharshan  1 , C Hanstock, B Hui, T Pyra, W Johnston, S Kalra
Affiliations

Degeneration of the mid-cingulate cortex in amyotrophic lateral sclerosis detected in vivo with MR spectroscopy

N Sudharshan et al. AJNR Am J Neuroradiol. 2011 Feb.

Abstract

Background and purpose: Various lines of evidence implicate cerebral involvement beyond the motor cortex in ALS, including the cingulate gyrus and the thalamus. The purpose of this study was to assess neurodegeneration in these regions in vivo by using MRSI.

Materials and methods: Fourteen patients with ALS and 14 healthy controls underwent MRSI by using a coronal acquisition scheme. The NAA/Cho ratio was quantified in the MCC, thalamus, and motor cortex (PCG).

Results: NAA/Cho was reduced in the MCC in patients with ALS compared with the controls (P = .0004). There was no difference in NAA/Cho in the thalamus (P = .59). We also found a strong correlation of NAA/Cho among the PCG, MCC, and the thalamus in controls, which was absent in patients with ALS.

Conclusions: Neurodegeneration beyond the motor cortex is present in the MCC in ALS. The significant correlation of NAA/Cho among the PCG, MCC, and the thalamus in healthy subjects likely reflects the neuronal connectivity among these regions. The loss of these relationships in patients with ALS suggests that such connectivity is not responsible for the pattern of degeneration in these regions.

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Figures

Fig 1.
Fig 1.
Spectroscopic imaging. A coronal MR image is shown on the left demonstrating placement of the volume of interest (thick white border). Voxels identified for analysis included those in the PCG (squares), MCC (open circles), and thalamus (closed circles). A representative spectrum from each of these regions is presented on the right from a control subject and a patient with ALS.
Fig 2.
Fig 2.
Loss of neurochemical associations among regions in patients with ALS. Strong correlations of NAA/Cho are present among regions in healthy control subjects (open circles); whereas, in patients (closed circles, regression coefficients not displayed) significant correlations are not observed.
See this image and copyright information in PMC

References

    1. Ringholz GM, Appel SH, Bradshaw M, et al. . Prevalence and pattern of cognitive impairment in sporadic ALS. Neurology 2005;65:586–90 - PubMed
    1. Strong MJ. The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2008;9:323–38 - PubMed
    1. Kiernan JA, Hudson AJ. Frontal lobe atrophy in motor neuron diseases. Brain 1994;117(pt 4):747–57 - PubMed
    1. Ikemoto A, Hirano A, Akiguchi I. Neuropathology of amyotrophic lateral sclerosis with extra-motor system degeneration: characteristics and differences in the molecular pathology between ALS with dementia and Guamanian ALS. Amyotroph Lateral Scler Other Motor Neuron Disord 2000;1:97–104 - PubMed
    1. Ellis CM, Suckling J, Amaro E, Jr, et al. . Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS. Neurology 2001;57:1571–78 - PubMed

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