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. 2010 Dec;134(6):873-9.
doi: 10.1309/AJCPPPR57HNJMSLZ.

Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade

Elizabeth M Genega  1 , Musie Ghebremichael, Robert Najarian, Yineng Fu, Yihong Wang, Pedram Argani, Chiara Grisanzio, Sabina Signoretti
Affiliations

Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade

Elizabeth M Genega et al. Am J Clin Pathol. 2010 Dec.

Abstract

Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P < .01) and primary (P < .01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade.

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Figures

Figure 1
Figure 1
Example of a low-grade clear cell renal cell carcinoma predominantly constituted by cells with clear cytoplasm (hematoxylin and eosin 10x) (A). CAIX expression is detected in the vast majority of tumor cells (10x) (B).
Figure 2
Figure 2
Example of a high-grade clear cell renal cell carcinoma predominantly constituted by cells with eosinophilic cytoplasm (hematoxylin and eosin 4x) (A). CAIX expression is detected in a small percentage of tumor cells (4x) (B).
Figure 3
Figure 3
Example of a papillary renal cell carcinoma (hematoxylin and eosin 10x) (A), with focal expression of CAIX (10x) (B).
See this image and copyright information in PMC

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