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Comparative Study
. 2010;24(6):418-21.
doi: 10.1002/jcla.20422.

Evaluation of BD Vacutainer SST™ II Plus tubes for common tumor marker tests by Roche Diagnostics Modular E 170 analyzer

Zhiyan Li  1 , Zhenru Feng, Cunling Yan, Rong Yan
Affiliations
Comparative Study

Evaluation of BD Vacutainer SST™ II Plus tubes for common tumor marker tests by Roche Diagnostics Modular E 170 analyzer

Zhiyan Li et al. J Clin Lab Anal. 2010.

Abstract

Serum separator tubes were introduced 35 years ago and were widely used in the clinical laboratory in China for routine collection of blood because of providing a closed system that allowed for collection, transport, processing, sampling, and storage of specimens. This type of tubes facilitated rapid separation of serum from cellular constituents of blood and also prevented hemolysis upon prolonged storage. However, there were some limitations associated with gel tubes (i.e., gel and analyte stability). In order to circumvent these problems, BD released a new serum separator tube containing a new gel (BD SST(™) II Plus). We investigated the performance of BD SST(™) II Plus tubes for tumor marker tests using BD Serum Glass tubes as controls. Equivalence between the BD SST(™) II Plus and BD Serum Glass tubes was demonstrated for all analytes at initial time. Also, all analytes remained stable when stored in BD SST(™) II Plus tubes up to 72 hr. Concentration of neuron-specific enolase tended to increase with preservation time up to 72 hr in BD Serum Glass tubes. We conclude that BD SST(™) II Plus was suitable for collection of blood and storage of serum for tumor marker tests.

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References

    1. NCCLS Document H18‐A2 . Procedures for the Handling and Processing of Blood Specimens; Approved Guideline, second edition Wayne, PA: National Committee for Clinical Laboratory Standards, 1999.
    1. Ferry JD, Collins S, Sykes E. Effect of serum volume and time of exposure to gel barrier tubes on results for progesterone by Roche Diagnostics Elecsys 2010. Clin Chem 1999;45:1574–1575. - PubMed
    1. Dasgupta A, Dean R, Saldana S, et al. Absorption of therapeutic drugs by barrier gels in serum separator blood collection tubes. Am J Clin Pathol 1994;101:456–461. - PubMed
    1. Dasgupta A, Wells A, Bush V. Stability of therapeutic drugs on serum separator tubes from BD containing a new gel formulation. J Ther Drug Monit 1999;21:428. - PubMed
    1. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;i:307–310. - PubMed