Markers di stress ossidativo nei liquidi biologici. (Markers of oxidative stress in biological fluids)

Abstract

The damaging effects of free radicals (FR) in the perinatal period may be detected by testing specific markers of oxidative stress (OS) in newborn's biological fluids. Currently, more than 70 different markers are used to assess both the damage caused by excessive production of FR and body's antioxidant response. Our goal is to identify reliable markers for the detection of OS in physiology and pathology. These biomarkers can be useful for several clinical purpose such as to monitor the response to any antioxidant intervention and then develop preventive strategies. The standardization and a large clinical use of these biomarkers should contribute to the daily neonatologists work in the early detection, management and therapy of the several neonatal FR diseases.